Author:
Sun Mingji,Xue Cheng,Lu Yunhui,Ma Yiyi,Pan Ting,Wang Xiaoliu,Fan Li,Shen Jiandong,Hao Yan,Zheng Danxia,Li Junhua,Li Mingxu,He Yaping,Mei Changlin
Abstract
Abstract
Background
With the development and progression of genetic technology, preimplantation genetic testing (PGT) has made it possible to block the inheritance of autosomal dominant polycystic kidney disease (ADPKD) as early as possible. However, we need to know the patients’ fertility intentions and their acceptance of PGT.
Methods
A questionnaire survey was conducted to collect data on the basic demographic data, quality of life, social support, fertility willingness, and level of understanding of genetic testing for blocking the inheritance of ADPKD among patients aged 18–45 years in seven hospitals from January 2018 to December 2018. After verification, statistics were calculated.
Results
A total of 260 patients with ADPKD were interviewed, including 137males (52.7%) and 123 females (47.3%). The overall fertility willingness rate was low (n = 117, 45.0%). The proportion of married patients aged 25–34 years that were at the optimal reproductive age but did not yet have children was relatively high (n = 77, 67.0%). The fertility intentions of ADPKD patients were significantly influenced by age (OR: 0.101, 95% CI 0.045–0.225, P < 0.001) and education level (OR: 2.134, 95% CI 1.162–3.917, P = 0.014). Among patients who are willing to have children, 207 (79.6%) of them would choose PGT technology. Among those who were not sure whether they would choose PGT technology, the first major concern was technical safety (49.2%).
Conclusions
The reproductive desire of childbearing ADPKD patients in China was low. Strengthening the health education of ADPKD genetic knowledge and reducing the cost of related technologies may improve the fertility intentions and reduce the barriers to acceptance of PGT.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Shanghai Top Priority Key Clinical Disciplines Construction Project
Shanghai Science and Technology Talents Program
Shanghai Shenkang Hospital Development Center Clinical Science and Technology Innovation Project
Publisher
Springer Science and Business Media LLC
Cited by
7 articles.
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