Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

Author:

El-Husseiny Moustafa Fatma,Nagy Eman,Elwasif Salwa Mahmoud,Sobh Mohamed

Abstract

AbstractKaryomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.

Funder

Mansoura University

Publisher

Springer Science and Business Media LLC

Subject

Nephrology

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