Author:
Goh Kim Ling,Abeyaratne Asanga,Ullah Shahid,Rissel Chris,Priyadarshana Kelum
Abstract
Abstract
Aim
Royal Darwin Hospital (RDH) is the main tertiary hospital that has performed more than 600 biopsies since its establishment. Although Indigenous people in Australia’s Northern Territory (NT) has the highest rate of renal replacement therapy, the histopathology pattern of their renal diseases is still under discussed. We aimed to analyse the histopathology pattern of patients undergoing renal biopsy in RDH from June 2007 to June 2020. Secondary aims include clinical indication and survival analysis of patients with kidney biopsies.
Methods
We conducted a retrospective cohort study on all native kidney biopsy reports from patients over the age of 16, from June 2007 to June 2020. Descriptive statistics was used to summarise age, sex, indigeneity, histopathological pattern, and mortality. Categorical values were expressed as absolute frequencies and percentages. Survival analysis was performed using multivariate analyses and Cox proportional hazard regression model.
Results
There were 364 native renal biopsies included in the analysis. Sub-nephrotic proteinuria was the most common clinical indication for kidney biopsy (n = 160,47.8%). Diabetes nephropathy (DN) was the most common pathological finding (n = 71,12.8%). Indigenous population who had dialysis performs poorly compared to their non-indigenous counterpart (HR 2.37,95% CI 1.53–3.67,p < 0.001).
Conclusion
Diabetic nephropathy is the most common native kidney biopsy in the NT with higher mortality among indigenous patients. This study supports the previous findings of indigenous female excess, younger age of kidney disease requiring kidney biopsy, and excess of diabetic nephropathy in the top-end of the NT. It can be speculated that some diabetic patients had atypical features prompting a biopsy.
Publisher
Springer Science and Business Media LLC
Reference14 articles.
1. Luciano RL, Moeckel GW. Update on the native kidney biopsy: core curriculum 2019. Am J Kidney Dis. 2019;73(3):404–15.
2. Charles Darwin University. A multicultural northern territory- statistics from the 2016 census, Available at: https://www.cdu.edu.au/northern-institute/multicultural-northern-territory. (Accessed: 4 Dec 2020).
3. Cunningham A, Benediktsson H, Muruve DA, Hildebrand AM, Pietro RP. Trends in biopsy-based diagnosis of kidney disease: a population study. Can J Kidney Health Dis. 2018;5:1–9.
4. Hu R, Quan S, Wang Y, Zhou Y, et al. Spectrum of biopsy proven renal diseases in Central China: a 10 year retrospective study based on 34,630 cases. Nat Res. 2020;10:10994.
5. Habib MA, Badruddoza SM. Pattern of glomerular diseases among adults in Rajshahi, the Northern region of Bangladesh. Saudi J Kidney Dis Transpl. 2012;23:876–80.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献