Author:
Turgutalp Kenan,Cebeci Egemen,Turkmen Aydin,Derici Ulver,Seyahi Nurhan,Eren Necmi,Dede Fatih,Gullulu Mustafa,Basturk Taner,Sahin Gulizar Manga,Yilmaz Murvet,Sipahi Savas,Sahin Garip,Ulu Sena,Tatar Erhan,Gundogdu Ali,Kazancioglu Rumeyza Turan,Sevinc Can,Gungor Ozkan,Sahin İdris,Kutlay Sim,Kurultak Ilhan,Aydin Zeki,Altun Bulent,Dursun Belda,Yilmaz Zulfikar,Uzun Ozcan,Suleymanlar Gultekin,Candan Ferhan,Sezer Siren,Tanburoglu Derya Basak,Bahcebasi Zerrin Bicik,Taymez Dilek,Akcali Esra,Oygar Deren,Istemihan Zulal,Bardak Simge,Akcay Omer Faruk,Dincer Mevlut Tamer,Dervisoglu Erkan,Yenigun Ezgi,Turkmen Kultigin,Ozturk Savas
Abstract
Abstract
Background
Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis.
Methods
A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated.
Results
81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = − 0.084, r = − 0.102, r = − 0.006, r = 0.062, r = 0.014, r = − 0.044, r = − 0.061, r = − 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05).
Conclusion
Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.
Publisher
Springer Science and Business Media LLC
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