Author:
Yan Yongqin,Wang Cheng,Zheng Zhiyong,Qu Lijuan,Zeng Dehua,Li Min
Abstract
Abstract
Background
To investigate the clinicopathological characteristics of renal damage caused by long-term exposure to carbon disulfide (CS2) in nine patients.
Methods
All the patients underwent ultrasound-guided renal biopsy. All specimens were examined by light microscopy and immunohistochemistry (IHC). Samples form one patient were further analyzed using transmission electron microscopy.
Results
Similar pathological changes were observed in all patients, but the degrees of lesions were different. All cases had moderate to severe nodular mesangial hyperplasia; among these, type “Kimme1stie1-Wi1son” (K-W nodule for short) was observed in four cases, type “K - W nodule” refer to nodular hyperplasia of mesangial membrane like letter K or W. four cases had proliferative extracapillary glomerulonephritis (GN), while there were no concomitant changes in one patient. Besides, six cases had diffuse basement membrane thickening, focal segmental sclerosis or bulbar sclerosis; two cases had diffuse glomerular sclerosis, and one case had focal segmental capillary hyperplasia. Moreover, all patients had renal tubular atrophy/interstitial fibrosis with less to moderate chronic inflammatory cell infiltration, as well as renal arteriosclerosis. IHC showed that the depositions of IgA, IgM, C3d, C4d, C1q and Fib were not specific; while IgG, type III collagen, Fibronectin, Amyloid A, Igκ, Igλ, HBsAg and HBcAg were all negative.
Conclusion
Diffuse nodular mesangial hyperplasia/sclerosing glomerular nephropathy is characterized by nodular mesangial hyperplasia with type “K-W nodules” formation, which we speculate is a special pathological manifestation of renal damage caused by carbon disulfide (CS2).
Funder
Clinicopathological study of carbon disulfide chronic toxic nephropathy
Publisher
Springer Science and Business Media LLC
Reference19 articles.
1. Gelbke HP, Goen T, Maurer M, Sulsky SI. A review of health effects of carbon disulfide in viscose industry and a proposal for an occupational exposure limit. Crit Rev Toxicol. 2009;39(Suppl 2):1–126.
2. Chuang WL, Huang CC, Chen CJ, Hsieh YC, Kuo HC, Shih TS. Carbon disulfide encephalopathy: cerebral microangiopathy. Neurotoxicology. 2007;28(2):387–93.
3. Klemmer PJ, Harris AA. Carbon disulfide nephropathy. Am J Kidney Dis. 2000;36(3):626–9.
4. Zhang R, Zheng ZY, Lin JS, Qu LJ, Zheng F. The continual presence of C3d but not IgG glomerular capillary deposition in stage I idiopathic membranous nephropathy in patients receiving corticosteroid treatment. Diagn Pathol. 2012;7:109.
5. Wang C, Zheng ZY, Zeng L. XXIV protease in renal biopsy paraffin sections HBV immunization group (HWD1.1) and fibronectin were digested with 0.05% 24-type protease for 10 minutes. Acta Clin Exper Pathol. 2007;23(4):496.
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