Author:
Verdier Jean-François,Boyer Sonia,Chalmin Florence,Jeribi Ahmed,Egasse Caroline,Maggi Marie France,Auvray Philippe,Yalaoui Tarik
Abstract
Abstract
Background
The mortality rate associated with coronavirus disease 2019 (COVID-19) is high among haemodialyzed patients. We sought to describe the serological status of haemodialysis patients having received up to three doses of BNT162b2 mRNA vaccine, and to identify factors associated with a poor humoral response.
Methods
We performed a retrospective, observational study of patients attending a dialysis centre in Antibes, France. One or two of each patient’s monthly venous blood samples were assayed for anti–spike (S1) immunoglobulin G (IgG).
Results
We included 142 patients, of whom 124 remained COVID-19-negative throughout the study. Among these COVID-19-negative patients, the humoral immune response rate (defined as an anti-S1 IgG titre ≥1.2 U/ml) was 82.9% after two injections and 95.8% after three injections, and the median [interquartile range] titre increased significantly from 7.09 [2.21; 19.94] U/ml with two injections to 93.26 [34.25; 176.06] U/ml with three. Among patients with two injections, the mean body mass index and serum albumin levels were significantly higher in responders than in non-responders (26.5 kg/m2 vs. 23.2 kg/m2, p = 0.0392; and 41.9 g/l vs. 39.0 g/l, p = 0.0042, respectively). For the study population as a whole at the end of the study, a history of COVID-19, at least two vaccine doses, and being on the French national waiting list for kidney transplantation were the only factors independently associated with the anti-S1 IgG titre.
Conclusions
Dialysis patients vaccinated with two doses of BNT162b2 might not be sufficiently protected against SARS-CoV-2 and so should receive a third (booster) dose.
Trial registration
The present retrospective study of clinical practice was not interventional and so was not registered.
Publisher
Springer Science and Business Media LLC
Cited by
13 articles.
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