Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis-Reference-Cited by-同舟云学术

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Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Published:2014-07-21 Issue:1 Volume:11 Page:
ISSN:1742-2094
Container-title:Journal of Neuroinflammation
language:en
Short-container-title:J Neuroinflammation

Author:

Mc Guire Conor,Elton Lynn,Wieghofer Peter,Staal Jens,Voet Sofie,Demeyer Annelies,Nagel Daniel,Krappmann Daniel,Prinz Marco,Beyaert Rudi,van Loo Geert

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology,Immunology,General Neuroscience

Link

https://link.springer.com/content/pdf/10.1186/1742-2094-11-124.pdf

Reference26 articles.

1. Trapp BD, Nave KA: Multiple sclerosis: an immune or neurodegenerative disorder?. Annu Rev Neurosci. 2008, 31: 247-269. 10.1146/annurev.neuro.30.051606.094313.

2. Mc Guire C, Volckaert T, Wolke U, Sze M, De Rycke R, Waisman A, Prinz M, Beyaert R, Pasparakis M, van Loo G: Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination. J Immunol. 2010, 185: 7646-7653. 10.4049/jimmunol.1000930.

3. Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, Sun L, Chen ZJ, Marynen P, Beyaert R: T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol. 2008, 9: 263-271.

4. Hailfinger S, Nogai H, Pelzer C, Jaworski M, Cabalzar K, Charton JE, Guzzardi M, Decaillet C, Grau M, Dorken B, Lenz P, Lenz G, Thome M: Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci U S A. 2011, 108: 14596-14601. 10.1073/pnas.1105020108.

5. Rebeaud F, Hailfinger S, Posevitz-Fejfar A, Tapernoux M, Moser R, Rueda D, Gaide O, Guzzardi M, Iancu EM, Rufer N, Fasel N, Thome M: The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol. 2008, 9: 272-281. 10.1038/ni1568.

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