Author:
Piccirilli Giulia,Gennari Monia,Gabrielli Liliana,Leone Marta,Borgatti Eva Caterina,Cantiani Alessia,Lanna Federica,Magurano Fabio,Baggieri Melissa,Marangoni Antonella,Lanari Marcello,Lazzarotto Tiziana
Abstract
AbstractMeasles virus (MV) and cytomegalovirus (CMV) may cause pediatric infection. We report the first described case of MV and CMV co-infection in an unvaccinated 13-mo-old girl, with a recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, occurred during coronavirus disease 2019 (COVID-19) pandemic. The COVID-19 pandemic context, combined with patient’s complex clinical scenario, presenting symptoms as persistent fever, diarrhea, vomiting, maculopapular rash and edema, in addition to high level of inflammatory markers, led to a suspicion of multisystemic inflammatory syndrome in children (MIS-C). The final diagnosis and the successfully management of the case, discharged after resolution of symptoms, was achieved by a proper virological diagnosis and a close two-way cooperation between pediatricians and clinical microbiologists. The report mainly highlights that awareness about measles should be raised in unvaccinated patients with consistent symptoms, even in the COVID-19 era.
Funder
This research was supported by EU funding within the NextGenerationEU-MUR PNRR Extended Partnership initiative on Emerging infectious Diseases
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Reference18 articles.
1. -Tuna Kirsaclioglu C, Hizal G, Karakus E, Sayli TR. An unusual presentation of cytomegalovirus infection: generalized Edema. Med Princ Pract. 2020;29(1):94–6. https://doi.org/10.1159/000500511. Epub 2019 Apr 24. PMID: 31013510; PMCID: PMC7024873.
2. -CDC. Epidemiology and Prevention of Vaccine-Preventable Diseases. Measles. Paul Gastanaduy, Penina Haber, Paul A. Rota, and Manisha Patel. Available from: https://www.cdc.gov/vaccines/pubs/pinkbook/meas.html.
3. -Rabaan AA, Mutair AA, Alhumaid S, Garout M, Alsubki RA, Alshahrani FS, Alfouzan WA, Alestad JH, Alsaleh AE, Al-Mozaini MA, Koritala T, Alotaibi S, Temsah MH, Akbar A, Ahmad R, Khalid Z, Muhammad J, Ahmed N. Updates on Measles Incidence and Eradication: Emphasis on the Immunological Aspects of Measles Infection. Medicina (Kaunas). 2022 May 20;58(5):680. https://doi.org/10.3390/medicina58050680. PMID: 35630096; PMCID: PMC9147347.
4. -Rota PA, Brown K, Mankertz A, Santibanez S, Shulga S, Muller CP, Hübschen JM, Siqueira M, Beirnes J, Ahmed H, et al. Global distribution of measles genotypes and Measles Molecular Epidemiology. J Infect Dis. 2011;204:514–S523.
5. -Gökçe Ş, Kurugöl Z. Cytomegalovirus-Associated Menetrier Disease in Childhood. Clin Pediatr (Phila). 2017 Apr;56(4):382–384. https://doi.org/10.1177/0009922816657155. Epub 2016 Jul 18. PMID: 27380791.