Author:
Collender Phillip,Bozack Anne K.,Veazie Stephanie,Nwanaji-Enwerem Jamaji C.,Van Der Laan Lars,Kogut Katherine,Riddell Corinne,Eskenazi Brenda,Holland Nina,Deardorff Julianna,Cardenas Andres
Abstract
Abstract
Background
Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational health effects by which parental ACEs are associated with mental and physical health of children. Epigenetic programming may be one mechanism linking parental ACEs to child health. This study aimed to investigate epigenome-wide associations of maternal preconception ACEs with DNA methylation patterns of children. In the Center for the Health Assessment of Mothers and Children of Salinas study, cord blood DNA methylation was measured using the Illumina HumanMethylation450 BeadChip. Preconception ACEs, which occurred during the mothers’ childhoods, were collected using a standard ACE questionnaire including 10 ACE indicators. Maternal ACE exposures were defined in this study as (1) the total number of ACEs; (2) the total number of ACEs categorized as 0, 1–3, and > 4; and (3) individual ACEs. Associations of ACE exposures with differential methylated positions, regions, and CpG modules determined using weighted gene co-expression network analysis were evaluated adjusting for covariates.
Results
Data on maternal ACEs and cord blood DNA methylation were available for 196 mother/newborn pairs. One differential methylated position was associated with maternal experience of emotional abuse (cg05486260/FAM135B gene; q value < 0.05). Five differential methylated regions were significantly associated with the total number of ACEs, and 36 unique differential methylated regions were associated with individual ACEs (Šidák p value < 0.05). Fifteen CpG modules were significantly correlated with the total number of ACEs or individual ACEs, of which 8 remained significant in fully adjusted models (p value < 0.05). Significant modules were enriched for pathways related to neurological and immune development and function.
Conclusions
Maternal ACEs prior to conception were associated with cord blood DNA methylation of offspring at birth. Although there was limited overlap between differential methylated regions and CpGs in modules associated with ACE exposures, statistically significant regions and networks were related to genes involved in neurological and immune function. Findings may provide insights to pathways linking psychosocial stressors to health. Further research is needed to understand the relationship between changes in DNA methylation and child health.
Funder
National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Developmental Biology,Genetics,Molecular Biology
Reference98 articles.
1. CDC National Center for Injury Prevention and Control, Division of Violence Prevention. Fast Facts: Preventing Adverse Childhood Experiences [Internet]. 2023. Available from: https://www.cdc.gov/violenceprevention/aces/fastfact.html
2. Giano Z, Wheeler DL, Hubach RD. The frequencies and disparities of adverse childhood experiences in the U.S. BMC Public Health. 2020;20:1327.
3. Kidman R, Piccolo LR, Kohler H-P. Adverse childhood experiences: prevalence and association with adolescent health in Malawi. Am J Prev Med. 2020;58:285–93.
4. LaBrenz CA, O’Gara JL, Panisch LS, Baiden P, Larkin H. Adverse childhood experiences and mental and physical health disparities: the moderating effect of race and implications for social work. Soc Work Health Care. 2020;59:588–614.
5. Soares S, Rocha V, Kelly-Irving M, Stringhini S, Fraga S. Adverse childhood events and health biomarkers: a systematic review. Front Public Health. 2021;9:649825.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献