Author:
Jin Xiaochun,Wu Yueyuan,Yin Shuzhou,Chen Xu,Zhang Youtao
Abstract
Abstract
Background
Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (− 1082 G/A, − 819 C/T, − 592C/A) and IL-6 -174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility.
Methods
Both OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The χ2-test based Q-statistic and I2 statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used.
Results
The significant associations were only found in Asian population of − 819 loci under three genetic models as follows: (Allele model: OR = 0.60, 95%CI = 0.44–0.82, P = 0.001), (homozygote comparison: OR = 0.24, 95%CI = 0.09–0.62, P = 0.003), (recessive genetic model: OR = 0.22, 95%CI = 0.05–0.91, P = 0.036).
Conclusion
In conclusion, IL-10 − 819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10 -1082 G/A, 592 loci and IL-6 -174 G/C polymorphism are not associated with Brucellosis risk.
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics
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