Author:
Vannice Kirsten S,Brown Graham V,Akanmori Bartholomew D,Moorthy Vasee S
Abstract
Abstract
The World Health Organization (WHO) convened a malaria vaccines committee (MALVAC) scientific forum from 20 to 21 February 2012 in Geneva, Switzerland, to review the global malaria vaccine portfolio, to gain consensus on approaches to accelerate second-generation malaria vaccine development, and to discuss the need to update the vision and strategic goal of the Malaria Vaccine Technology Roadmap. This article summarizes the forum, which included reviews of leading Plasmodium falciparum vaccine candidates for pre-erythrocytic vaccines, blood-stage vaccines, and transmission-blocking vaccines. Other major topics included vaccine candidates against Plasmodium vivax, clinical trial site capacity development in Africa, trial design considerations for a second-generation malaria vaccine, adjuvant selection, and regulatory oversight functions including vaccine licensure.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Parasitology
Reference11 articles.
1. Malaria Vaccine Technology Roadmap: http://www.malariavaccine.org/files/Malaria_Vaccine_TRM_Final.pdf.
2. World Health Organization:Most advanced malaria vaccine candidate and timing for policy recommendations. http://www.who.int/vaccine_research/diseases/malaria/vaccine_candidate_policy/en/index.html.,
3. malERA:A research agenda for malaria eradication. PLoS Med. 2011, 8 (1): 1-99.
4. Laurens MB, Roestenberg M, Moorthy VS, The Consensus Group on Design of Clinical Trials of Controlled Human Malaria Infection: A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines. Vaccine. 2012, 30 (36): 5302-5304. 10.1016/j.vaccine.2012.04.088.
5. World Health Organization: NIAID/WHO Workshop on Heterologous Prime-Boost Strategies for HIV, Malaria and Tuberculosis Vaccines. http://www.who.int/vaccine_research/diseases/malaria/niaid_workshop_hiv_malaria_tb_2012/en/index.html.
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