Author:
Flores Angélica,Rodríguez Jorge O,Palafox María T,Meléndez Griselda,Barco Ana I,Chavira Roberto,Esther Cruz M,Domínguez Roberto
Abstract
Abstract
The presence of asymmetry in the capacity of the left and right ovaries to secrete testosterone was analyzed by studying the effects of hemiovariectomy along the estrus cycle one hour after surgery. The effects of ether anesthesia on hormone serum levels were also analyzed.
Bilateral ovariectomy and the extirpation of the left ovary performed on the day of proestrus resulted in significantly lower testosterone levels.
Compared to the anesthetized group, the effects of perforating the peritoneum unilaterally varied according to the day of the estrous cycle and the side of the peritoneum surgery was performed on. Injecting atropine sulfate (ATR) to control or anesthetized rats on D1 resulted in a significant increase of testosterone serum levels.
The effects of perforating the peritoneum on testosterone levels depended on the cholinergic innervation and varied along the estrous cycle. Blocking the cholinergic system before performing unilateral or bilateral ovariectomy had different effects depending on the day of the estrous cycle. Testosterone plasma levels increased significantly when surgery was performed on the day of diestrus and dropped when surgery was performed on proestrus. Similar effects were observed when the left adrenal was extirpated from animals with the cholinergic system blocked. The results presented herein support the hypothesis of asymmetry in the ovaries' abilities to secrete steroid hormones, and that the capacity to secrete testosterone varies along the estrous cycle.
Publisher
Springer Science and Business Media LLC
Subject
Developmental Biology,Endocrinology,Reproductive Medicine,Obstetrics and Gynaecology
Reference25 articles.
1. diZerega GS, Lynch A, Hodgen GD: Initiation of asymmetrical ovarian estradiol secretion in the primate ovarian cycle after luteectomy. Endocrinology. 1981, 108: 1233-1236.
2. Domínguez R, Morales L, Cruz ME: Ovarian Asymmetry. Ann Rev Biomed Sci. 2003, 5: 95-104.
3. Domínguez R, Cruz ME, Chávez R: Differences in the ovulatory ability between the right and left ovary are related to ovarian innervation. Growth Factors and the Ovary. Edited by: Hirshfield AN. 1988, Plenum Press: New York, 39: 321-325.
4. Rao CV, Edgerton LA: Dissimilarity of corpora lutea within the same ovaries or those from right and left ovaries of pigs during the oestrous cycle. Reprod Fertil. 1984, 70 (1): 61-66.
5. Barco AI, Flores A, Chavira R, Damian-Matzumura P, Domínguez R, Cruz ME: Asymmetric effects of acute hemiovariectomy on steroid hormone secretion by the in situ ovary. Endocrine. 2003, 21 (3): 209-215. 10.1385/ENDO:21:3:209.
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