Author:
Liu Chunmei,Wang Jing,Zhou Sirui,Wang Binbin,Ma Xu
Abstract
Abstract
Objectives
TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy.
Study Design
A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis.
Results
lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -238 polymorphism.
Conclusion
This study suggested that TNF-alpha may be a risk factor in Chinese RSA patients. However the ethnic differences may also contribute to the results.
Publisher
Springer Science and Business Media LLC
Subject
Developmental Biology,Endocrinology,Reproductive Medicine,Obstetrics and Gynecology
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