The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity-Reference-Cited by-同舟云学术

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

Published:2017-11-09 Issue:1 Volume:14 Page:
ISSN:1742-4690
Container-title:Retrovirology
language:en
Short-container-title:Retrovirology

Author:

Amadori Céline,van der Velden Yme Ubeles,Bonnard Damien,Orlov Igor,van Bel Nikki,Le Rouzic Erwann,Miralles Laia,Brias Julie,Chevreuil Francis,Spehner Daniele,Chasset Sophie,Ledoussal Benoit,Mayr Luzia,Moreau François,García Felipe,Gatell José,Zamborlini Alessia,Emiliani Stéphane,Ruff Marc,Klaholz Bruno P.,Moog Christiane,Berkhout Ben,Plana Montserrat,Benarous Richard^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Link

http://link.springer.com/content/pdf/10.1186/s12977-017-0373-2.pdf

Reference45 articles.

1. Lesbats P, Engelman AN, Cherepanov P. Retroviral DNA integration. Chem Rev. 2016;116:12730–57.

2. Engelman A, Cherepanov P. The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS Pathog. 2008;4:e1000046.

3. Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, et al. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci. 2016;113:E1054–63.

4. Cherepanov P, Maertens G, Proost P, Devreese B, Jozef VB, Engelborghs Y, et al. HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J Biol Chem. 2003;278:372–81.

5. Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempé D, et al. Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication. J Biol Chem. 2005;280:25517–23.

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