Author:
Jia Lei,Liu Mengying,Yang Caiqin,Li Hanping,Liu Yongjian,Han Jingwan,Zhai Xiuli,Wang Xiaolin,Li Tianyi,Li Jingyun,Zhang Bohan,Yu Changyuan,Li Lin
Abstract
Abstract
Background
Human endogenous retroviruses (HERVs) result from ancestral infections caused by exogenous retroviruses that became incorporated into the germline DNA and evolutionarily fixed in the human genome. HERVs can be transmitted vertically in a Mendelian fashion and be stably maintained in the human genome, of which they are estimated to comprise approximately 8%. HERV-K (HML1-10) transcription has been confirmed to be associated with a variety of diseases, such as breast cancer, lung cancer, prostate cancer, melanoma, rheumatoid arthritis, and amyotrophic lateral sclerosis. However, the poor characterization of HML-9 prevents a detailed understanding of the regulation of the expression of this family in humans and its impact on the host genome. In light of this, a precise and updated HERV-K HML-9 genomic map is urgently needed to better evaluate the role of these elements in human health.
Results
We report a comprehensive analysis of the presence and distribution of HERV-K HML-9 elements within the human genome, with a detailed characterization of the structural and phylogenetic properties of the group. A total of 23 proviruses and 47 solo LTR elements were characterized, with a detailed description of the provirus structure, integration time, potential regulated genes, transcription factor binding sites (TFBS), and primer binding site (PBS) features. The integration time results showed that the HML-9 elements found in the human genome integrated into the primate lineage between 17.5 and 48.5 million years ago (mya).
Conclusion
The results provide a clear characterization of HML-9 and a comprehensive background for subsequent functional studies.
Funder
National Nature Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Cited by
9 articles.
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