Author:
Schmidt Jenna Kropp,Reynolds Matthew R.,Golos Thaddeus G.,Slukvin Igor I.
Abstract
AbstractNonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV.
Funder
NIH Office of the Director
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Heart, Lung, and Blood Institute
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Cited by
5 articles.
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