HIV-Tat immunization induces cross-clade neutralizing antibodies and CD4+ T cell increases in antiretroviral-treated South African volunteers: a randomized phase II clinical trial

Author:

Ensoli Barbara, ,Nchabeleng Maphoshane,Ensoli Fabrizio,Tripiciano Antonella,Bellino Stefania,Picconi Orietta,Sgadari Cecilia,Longo Olimpia,Tavoschi Lara,Joffe Daniel,Cafaro Aurelio,Francavilla Vittorio,Moretti Sonia,Pavone Cossut Maria Rosaria,Collacchi Barbara,Arancio Angela,Paniccia Giovanni,Casabianca Anna,Magnani Mauro,Buttò Stefano,Levendal Elise,Ndimande John Velaphi,Asia Bennett,Pillay Yogan,Garaci Enrico,Monini Paolo

Funder

General Directorate for Development Cooperation of the Italian Ministry of Foreign Affairs

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Reference113 articles.

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2. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. WHO web site. 2015. http://apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf . (Accessed 7 Apr 2016).

3. Gupta RK, Jordan MR, Sultan BJ, Hill A, Davis DH, Gregson J, Sawyer AW, Hamers RL, Ndembi N, Pillay D, Bertagnolio S. Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis. Lancet. 2012;380:1250–8.

4. Hocqueloux L, Avettand-Fènoël V, Jacquot S, Prazuck T, Legac E, Mélard A, Niang M, Mille C, Le Moal G, Viard JP, Rouzioux C, AC32 (Coordinated Action on HIV Reservoirs) of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS). Long-term antiretroviral therapy initiated during primary HIV-1 infection is key to achieving both low HIV reservoirs and normal T cell counts. J Antimicrob Chemother. 2013;68:1169–78.

5. Grinsztejn B, Hosseinipour MC, Ribaudo HJ, Swindells S, Eron J, Chen YQ, Wang L, Ou SS, Anderson M, McCauley M, Gamble T, Kumarasamy N, Hakim JG, Kumwenda J, Pilotto JH, Godbole SV, Chariyalertsak S, de Melo MG, Mayer KH, Eshleman SH, Piwowar-Manning E, Makhema J, Mills LA, Panchia R, Sanne I, Gallant J, Hoffman I, Taha TE, Nielsen-Saines K, Celentano D, Essex M, Havlir D, Cohen MS, HPTN 052-ACTG Study Team. Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. Lancet Infect Dis. 2014;14:281–90.

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