Cycling and activated CD8+ T lymphocytes and their association with disease severity in influenza patients

Author:

Liu Shuai,Huang Zhisheng,Fan Ruyue,Jia Ju,Deng Xiaoyan,Zou Xiaohui,Li Hui,Cao Bin

Abstract

Abstract Background T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity. Methods In a cohort of hospitalized influenza patients with varying degrees of severity, we characterized lymphocyte populations using flow cytometry. Results The numbers of cycling (Ki67+) T cells at the acute phase of severe influenza were higher, especially in the memory (CD45RO+) T cell subsets. T cells from hospitalized influenza patients also had significantly higher levels of the exhausted marker PD-1. Cycling status of T cells was associated with T cell activation during the acute phase of influenza infection. The recruitment of cycling and activated (CD38+HLA-DR+) CD8+ T cells subset is delayed in severe influenza patients. Conclusions The increased numbers of cycling memory (Ki67+CD45RO+) T cells subsets and delayed kinetics of activated (CD38+HLA-DR+) CD8+ T cells, could serve as possible biological markers for disease severity.

Funder

Research incubation Foundation of Shandong Provincial Hospital Affiliated to Shandong First Medical University

Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Immunology

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