Author:
Zhu Maoshu,Ma Yunhan,Tan Kai,Zhang Liyi,Wang Zhaowei,Li Yongsheng,Chen Yingyu,Guo Junjun,Yan Guoliang,Qi Zhongquan
Abstract
Abstract
Background
Miscellaneous memory cell populations that exist before organ transplantation are crucial barriers to transplantation. In the present study, we used a skin-primed heart transplantation model in mouse to evaluate the abilities of Thalidomide (TD), alone or in combination with co-stimulatory blockade, using monoclonal antibodies (mAbs) against memory T cells and alloantibodies to prolong the second cardiac survival.
Results
In the skin-primed heart transplantation model, TD combined with mAbs significantly prolonged the second cardiac survival, accompanied by inhibition of memory CD8+ T cells. This combined treatment enhanced the CD4+Foxp3+ regulatory T cells ratio in the spleen, restrained the infiltration of lymphocytes into the allograft, and suppressed the allo-response of spleen T cells in the recipient. The levels of allo-antibodies also decreased in the recipient serum. In addition, we detected low levels of the constitutions of the lytic machinery of cytotoxic cells, which cause allograft damage.
Conclusions
Our study indicated a potential synergistic action of TD in combination with with mAbs to suppress the function of memory T cells and increase the survival of second allografts in alloantigen-primed mice.
Funder
Natural Science Foundation of Fujian Province
Fujian Provincial Health Education Joint Research Project
National Natural Science Foundation of China
National Key R&D Program of China
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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