Author:
Li Shulin,Wang Fei,Sun Dong
Abstract
AbstractChronic kidney disease (CKD) affects 8–16% of the population worldwide and is characterized by fibrotic processes. Understanding the cellular and molecular mechanisms underpinning renal fibrosis is critical to the development of new therapeutics. Microvascular injury is considered an important contributor to renal progressive diseases. Vascular endothelium plays a significant role in responding to physical and chemical signals by generating factors that help maintain normal vascular tone, inhibit leukocyte adhesion and platelet aggregation, and suppress smooth muscle cell proliferation. Loss of the rich capillary network results in endothelial dysfunction, hypoxia, and inflammatory and oxidative effects and further leads to the imbalance of pro- and antiangiogenic factors, endothelial cell apoptosis and endothelial-mesenchymal transition. New techniques, including both invasive and noninvasive techniques, offer multiple methods to observe and monitor renal microcirculation and guide targeted therapeutic strategies. A better understanding of the role of endothelium in CKD will help in the development of effective interventions for renal microcirculation improvement. This review focuses on the role of microvascular injury in CKD, the methods to detect microvessels and the novel treatments to ameliorate renal fibrosis.
Funder
National Natural Science Foundation of China
the Youth Program of National Natural Science Foundation of China
the Jiangsu Provincial Natural Science Foundation
the Jiangsu Provincial Commission of Health and Family Planning
a project of the Jiangsu Provincial Commission of Health and Family Planning
a project of Qing Lan of Jiangsu Province; a project of “Liu Ge Yi” of Jiangsu Province
the project of “Liu Da Ren Cai Gao Feng” of Jiangsu Province, China
Shi Er Wu Ke Jiao Xing Wei Key Medical Personnel of Jiangsu Province
Municipal key research and development project of Xuzhou
the China Postdoctoral Science Foundation
Science and technology development fund of Affiliated Hospital of Xuzhou Medical University
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
14 articles.
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