Somatic mutations in renal cell carcinomas from Chinese patients revealed by targeted gene panel sequencing and their associations with prognosis and PD-L1 expression

Author:

Wang Jie1,Xi Jianzhong2,Zhang Hanshuo3,Li Juan2,Xia Yuchao4,Xi Ruibin5,Xi Zhijun1

Affiliation:

1. Department of Urology; Peking University First Hospital and Institute of Urology, National Research Center for Genitourinary Oncology; No 8, Xishiku Street, Xicheng District Beijing 100034 P. R. China

2. Department of Biomedical Engineering, College of Engineering; Peking University; Beijing 100871 P. R. China

3. Beijing Genex Health Technology Co., Ltd; Beijing 100195 P. R. China

4. Chongqing Institute of Innovation and Entrepreneurship for Precision Medicine; Chongqing 401336 P. R. China

5. School of Mathematical Sciences and Center for Statistical Science; Peking University; 5 Yiheyuan Road Beijing 100871 P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference11 articles.

1. Cancer Statistics, 2017;Siegel;CA Cancer J Clin.,2017

2. Report of cancer incidence and mortality in China, 2014;Chen;Zhonghua Zhong Liu Za Zhi.,2018

3. Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing;Wang;Cancer Cell Int.,2018

4. Comprehensive molecular characterization of clear cell renal cell carcinoma;Cancer Genome Atlas Research N;Nature.,2013

5. A combination of targeted enrichment methodologies for whole-exome sequencing reveals novel pathogenic mutations;Miya;Sci Rep.,2015

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