Cancer mortality in a Chinese population surrounding a multi-metal sulphide mine in Guangdong province: an ecologic study

Author:

Wang Mao,Song Hong,Chen Wei-Qing,Lu Ciyong,Hu Qianshen,Ren Zefang,Yang Yan,Xu Yanjun,Zhong Aiming,Ling Wenhua

Abstract

Abstract Background The Dabaoshan mine in the southeast of Guangdong Province, China, is at high risk of multi-metal pollutant discharge into a local river (Hengshihe) and the surrounding area. Following approximately 30 years of exposure to these metals, little is known regarding the subsequent health effects and risks for the local residents. In our present study, we have estimated the relationships between long-term environmental exposure to multiple heavy metals and the risk of cancer mortality in a Chinese population in the vicinity of Dabaoshan. Methods An ecologic study was performed. Between 2000-2007, a total population of 194,131 lived in the nine agricultural villages that surround the Hengshihe area. Heavy metals concentrations were determined in local environmental samples (water and crops) and whole blood taken from 1152 local residents of both a high-exposure area (HEA) and a low-exposure area (LEA). We calculated the rate ratio and standardized mortality ratios based on age- and gender-specific cancer mortality rates for the different reference populations (based on district, county and province). Simple, multiple linear and ridge regression models were used to evaluate the associations between exposure to multiple heavy metals and cancer mortality in the nine villages, after adjustment for age and sex. Results The geometric mean blood levels of cadmium and lead were measured at 24.10 μg/L and 38.91 μg/dL for subjects (n = 563) in the HEA and 1.87 μg/L and 4.46 μg/dL for subjects (n = 589) from the LEA, respectively (P < 0.001). The rate of mortality from all cancers in the HEA was substantially elevated in comparison with the corresponding mortality rate in the LEA for men (rate ratio = 2.13; 95% confidence intervals = 1.63 - 2.77) and women (2.83; 1.91 - 4.19); rates were also significantly elevated compared with the rate when compared to the entire Wengyuan County area, or the provincial reference population. In addition, mortality rates were significantly increased for stomach, lung and esophageal cancer in the HEA in comparison with the corresponding rates in the LEA, in Wengyuan County and the provincial reference population for men, women and both combined. Further analysis showed that there were significantly positive correlations between exposure to cadmium and lead and the risk of all-cancers and stomach cancer mortality among women and both sexes, whilst zinc exposure showed no association with the risk of site-specific cancer mortality in the nine villages evaluated. Conclusions The findings of this study reveal probable associations between long-term environmental exposure to both cadmium and lead and an increased risk of mortality from all cancer, as well as from stomach, esophageal and lung-cancers.

Publisher

Springer Science and Business Media LLC

Subject

Public Health, Environmental and Occupational Health

Reference64 articles.

1. Zhou JM, Dang Z, Tu YS, Liu CQ: Distrution and characteristics of heavy metals contamination in soils from Dabaoshan mine area. Journal of Agro-Environment Science. 2004, 23 (6): 1172-1176.

2. Wu YG, Lin CX, Tong XL, Lu W, Zhu LX: Environmental impacts of acid mine drainage from Dabaoshan Mine:I.Downstream aquatic ecosystem. Ecology and environment. 2005, 14 (2): 165-168.

3. Lin CX, Lu WZ, Wu YG: Environmental impacts of acid mine drainage from Dabaoshan Mine: II. Agricultural ecosystem. Ecology and Environment. 2005, 14 (2): 169-172.

4. Fu SM, Zhou YZ, Zhao YY, Zeng F, Gao QZ, Peng XZ: Study on heavy metals in soils contaminated by acid mine drainage from Dabaoshan mine, Guangdong. Environmental Science. 2007, 28 (4): 805-812.

5. Zeng FG: Chemistry and Cancer in the Environment and Cancer. 2004, Beijing: China science and techology press, 117-

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