Nosocomial tuberculosis transmission from 2006 to 2018 in Beijing Chest Hospital, China

Author:

Xie Zhongyao,Zhou Ning,Chi Yuqing,Huang Guofang,Wang Jingping,Gao Hui,Xie Na,Ma Qianhui,Yang Nan,Duan Zhenlan,Nie WenjuanORCID,Sun Zhaogang,Chu Naihui

Abstract

Abstract Introduction Strong evidence is lacking to support effectiveness of currently implemented tuberculosis infection prevention control (TB-IPC) measures for preventing nosocomial tuberculosis (TB) transmission. This 13-year analysis is the longest follow-up investigation to date to identify risk factors underlying nosocomial TB transmission. Methods We monitored all staff of Beijing Chest Hospital each year from 2006 to 2018. Age, gender, duration, department, education, income, respirator, ultraviolet, and ventilation were chosen as variables. Univariate cox regression, correlation analysis, and multivariate cox regression were analyzed sequentially. Results Using multivariable cox regression analysis, variables of income, ultraviolet germicidal irradiation (UVGI), natural ventilation and mechanical ventilation conferred significant protective effects, with odds ratios of 0.499, 0.058, 0.003, and 0.015, respectively (P < 0.05). Medical N95 respirator conferred an excellent protective effect, with an associated TB infection rate of 0%. Notably, inadequately maintained mechanical ventilation systems were less protective than natural ventilation systems. Conclusion UVGI, adequate ventilation, and use of medical N95 respirator may be risk factors of nosocomial TB transmission.

Funder

Key laboratory of capital medical university open research project and Beijing Tuberculosis & Thoracic Tumor Research Institute cultivation project, Beijing Hospital Authority Youth Programme

Tongzhou District’s Two Supreme Talent

13th Five National Major Scientific and Technological Projects

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health

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