Proceedings from the 2nd Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019

Author:

Canna Scott W.,Schulert Grant S.,de Jesus Adriana,Pickering Alex,Brunner Hermine,Gadina Massimo,Levine Stewart,Goldbach-Mansky Raphaela,Boutelle Jonathan,Sinha Rashmi,DeBenedetti Fabrizio,Grom Alexei,Gottlieb Beth,Yeung Rae,Riskalla Mona,Prahalad Sampath,Alehashemi Sara,Chandrakasan Shan,Vastert Bas,Kimura Yuki,Carlson Anna,Schumacher Emily,Minerva Regina,Pierce Jonathan,Pierce Kate,Martinez Zulayka,Cupp Kari,Bush Leah,Costello Wendy,DelGaizo Vincent,

Abstract

AbstractFor reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall disease control, children with Systemic Juvenile Idiopathic Arthritis (SJIA) are now increasingly diagnosed with life-threatening chronic complications, including hepatitis and lung disease (SJIA-LD). On October 3–4, 2019, a two-day meeting, NextGen Therapies for Systemic Juvenile Idiopathic Arthritis (SJIA) & macrophage activation syndrome (MAS) organized by the Systemic JIA Foundation (www.systemicjia.org/) in Washington, DC brought together scientists, clinicians, parents and FDA representatives with the objectives (1) to integrate clinical and research findings in MAS and SJIA-LD, and (2) to develop a shared understanding of this seemingly new pulmonary complication of SJIA. The current manuscript summarizes discussions and conclusions of the meeting.

Funder

SJIA Foundation

Publisher

Springer Science and Business Media LLC

Subject

Immunology and Allergy,Rheumatology,Pediatrics, Perinatology and Child Health

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