Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis
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Published:2022-03-07
Issue:1
Volume:20
Page:
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ISSN:1546-0096
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Container-title:Pediatric Rheumatology
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language:en
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Short-container-title:Pediatr Rheumatol
Author:
Soulsby William DanielORCID, Balmuri Nayimisha, Cooley Victoria, Gerber Linda M., Lawson Erica, Goodman Susan, Onel Karen, Mehta Bella, Abel N., Abulaban K., Adams A., Adams M., Agbayani R., Aiello J., Akoghlanian S., Alejandro C., Allenspach E., Alperin R., Alpizar M., Amarilyo G., Ambler W., Anderson E., Ardoin S., Armendariz S., Baker E., Balboni I., Balevic S., Ballenger L., Ballinger S., Balmuri N., Barbar-Smiley F., Barillas-Arias L., Basiaga M., Baszis K., Becker M., Bell-Brunson H., Beltz E., Benham H., Benseler S., Bernal W., Beukelman T., Bigley T., Binstadt B., Black C., Blakley M., Bohnsack J., Boland J., Boneparth A., Bowman S., Bracaglia C., Brooks E., Brothers M., Brown A., Brunner H., Buckley M., Buckley M., Bukulmez H., Bullock D., Cameron B., Canna S., Cannon L., Carper P., Cartwright V., Cassidy E., Cerracchio L., Chalom E., Chang J., Chang-Hoftman A., Chauhan V., Chira P., Chinn T., Chundru K., Clairman H., Co D., Confair A., Conlon H., Connor R., Cooper A., Cooper J., Cooper S., Correll C., Corvalan R., Costanzo D., Cron R., Curiel-Duran L., Curington T., Curry M., Dalrymple A., Davis A., Davis C., Davis C., Davis T., De Benedetti F., De Ranieri D., Dean J., Dedeoglu F., DeGuzman M., Delnay N., Dempsey V., DeSantis E., Dickson T., Dingle J., Donaldson B., Dorsey E., Dover S., Dowling J., Drew J., Driest K., Du Q., Duarte K., Durkee D., Duverger E., Dvergsten J., Eberhard A., Eckert M., Ede K., Edelheit B., Edens C., Edens C., Edgerly Y., Elder M., Ervin B., Fadrhonc S., Failing C., Fair D., Falcon M., Favier L., Federici S., Feldman B., Fennell J., Ferguson I., Ferguson P., Ferreira B., Ferrucho R., Fields K., Finkel T., Fitzgerald M., Fleming C., Flynn O., Fogel L., Fox E., Fox M., Franco L., Freeman M., Fritz K., Froese S., Fuhlbrigge R., Fuller J., George N., Gerhold K., Gerstbacher D., Gilbert M., Gillispie-Taylor M., Giverc E., Godiwala C., Goh I., Goheer H., Goldsmith D., Gotschlich E., Gotte A., Gottlieb B., Gracia C., Graham T., Grevich S., Griffin T., Griswold J., Grom A., Guevara M., Guittar P., Guzman M., Hager M., Hahn T., Halyabar O., Hammelev E., Hance M., Hanson A., Harel L., Haro S., Harris J., Harry O., Hartigan E., Hausmann J., Hay A., Hayward K., Heiart J., Hekl K., Henderson L., Henrickson M., Hersh A., Hickey K., Hill P., Hillyer S., Hiraki L., Hiskey M., Hobday P., Hoffart C., Holland M., Hollander M., Hong S., Horwitz M., Hsu J., Huber A., Huggins J., Hui-Yuen J., Hung C., Huntington J., Huttenlocher A., Ibarra M., Imundo L., Inman C., Insalaco A., Jackson A., Jackson S., James K., Janow G., Jaquith J., Jared S., Johnson N., Jones J., Jones J., Jones J., Jones K., Jones S., Joshi S., Jung L., Justice C., Justiniano A., Karan N., Kaufman K., Kemp A., Kessler E., Khalsa U., Kienzle B., Kim S., Kimura Y., Kingsbury D., Kitcharoensakkul M., Klausmeier T., Klein K., Klein-Gitelman M., Kompelien B., Kosikowski A., Kovalick L., Kracker J., Kramer S., Kremer C., Lai J., Lam J., Lang B., Lapidus S., Lapin B., Lasky A., Latham D., Lawson E., Laxer R., Lee P., Lee P., Lee T., Lentini L., Lerman M., Levy D., Li S., Lieberman S., Lim L., Lin C., Ling N., Lingis M., Lo M., Lovell D., Lowman D., Luca N., Lvovich S., Madison C., Madison J., Manzoni S. Magni, Malla B., Maller J., Malloy M., Mannion M., Manos C., Marques L., Martyniuk A., Mason T., Mathus S., McAllister L., McCarthy K., McConnell K., McCormick E., McCurdy D., Stokes P. Mc Curdy, McGuire S., McHale I., McMonagle A., McMullen-Jackson C., Meidan E., Mellins E., Mendoza E., Mercado R., Merritt A., Michalowski L., Miettunen P., Miller M., Milojevic D., Mirizio E., Misajon E., Mitchell M., Modica R., Mohan S., Moore K., Moorthy L., Morgan S., Dewitt E. Morgan, Moss C., Moussa T., Mruk V., Murphy A., Muscal E., Nadler R., Nahal B., Nanda K., Nasah N., Nassi L., Nativ S., Natter M., Neely J., Nelson B., Newhall L., Ng L., Nicholas J., Nicolai R., Nigrovic P., Nocton J., Nolan B., Oberle E., Obispo B., O’Brien B., O’Brien T., Okeke O., Oliver M., Olson J., O’Neil K., Onel K., Orandi A., Orlando M., Osei-Onomah S., Oz R., Pagano E., Paller A., Pan N., Panupattanapong S., Pardeo M., Paredes J., Parsons A., Patel J., Pentakota K., Pepmueller P., Pfeiffer T., Phillippi K., Marafon D. Pires, Phillippi K., Ponder L., Pooni R., Prahalad S., Pratt S., Protopapas S., Puplava B., Quach J., Quinlan-Waters M., Rabinovich C., Radhakrishna S., Rafko J., Raisian J., Rakestraw A., Ramirez C., Ramsay E., Ramsey S., Randell R., Reed A., Reed A., Reed A., Reid H., Remmel K., Repp A., Reyes A., Richmond A., Riebschleger M., Ringold S., Riordan M., Riskalla M., Ritter M., Rivas-Chacon R., Robinson A., Rodela E., Rodriquez M., Rojas K., Ronis T., Rosenkranz M., Rosolowski B., Rothermel H., Rothman D., Roth-Wojcicki E., Rouster-Stevens K., Rubinstein T., Ruth N., Saad N., Sabbagh S., Sacco E., Sadun R., Sandborg C., Sanni A., Santiago L., Sarkissian A., Savani S., Scalzi L., Schanberg L., Scharnhorst S., Schikler K., Schlefman A., Schmeling H., Schmidt K., Schmitt E., Schneider R., Schollaert-Fitch K., Schulert G., Seay T., Seper C., Shalen J., Sheets R., Shelly A., Shenoi S., Shergill K., Shirley J., Shishov M., Shivers C., Silverman E., Singer N., Sivaraman V., Sletten J., Smith A., Smith C., Smith J., Smith J., Smitherman E., Soep J., Son M., Spence S., Spiegel L., Spitznagle J., Sran R., Srinivasalu H., Stapp H., Steigerwald K., Rakovchik Y. Sterba, Stern S., Stevens A., Stevens B., Stevenson R., Stewart K., Stingl C., Stokes J., Stoll M., Stringer E., Sule S., Sumner J., Sundel R., Sutter M., Syed R., Syverson G., Szymanski A., Taber S., Tal R., Tambralli A., Taneja A., Tanner T., Tapani S., Tarshish G., Tarvin S., Tate L., Taxter A., Taylor J., Terry M., Tesher M., Thatayatikom A., Thomas B., Tiffany K., Ting T., Tipp A., Toib D., Torok K., Toruner C., Tory H., Toth M., Tse S., Tubwell V., Twilt M., Uriguen S., Valcarcel T., Van Mater H., Vannoy L., Varghese C., Vasquez N., Vazzana K., Vehe R., Veiga K., Velez J., Verbsky J., Vilar G., Volpe N., von Scheven E., Vora S., Wagner J., Wagner-Weiner L., Wahezi D., Waite H., Walker J., Walters H., Muskardin T. Wampler, Waqar L., Waterfield M., Watson M., Watts A., Weiser P., Weiss J., Weiss P., Wershba E., White A., Williams C., Wise A., Woo J., Woolnough L., Wright T., Wu E., Yalcindag A., Yee M., Yen E., Yeung R., Yomogida K., Yu Q., Zapata R., Zartoshti A., Zeft A., Zeft R., Zhang Y., Zhao Y., Zhu A., Zic C.,
Abstract
Abstract
Background
Social determinants of health (SDH) greatly influence outcomes during the first year of treatment in rheumatoid arthritis, a disease similar to polyarticular juvenile idiopathic arthritis (pJIA). We investigated the correlation of community poverty level and other SDH with the persistence of moderate to severe disease activity and functional disability over the first year of treatment in pJIA patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry.
Methods
In this cohort study, unadjusted and adjusted generalized linear mixed effects models analyzed the effect of community poverty and other SDH on disease activity, using the clinical Juvenile Arthritis Disease Activity Score-10, and disability, using the Child Health Assessment Questionnaire, measured at baseline, 6, and 12 months.
Results
One thousand six hundred eighty-four patients were identified. High community poverty (≥20% living below the federal poverty level) was associated with increased odds of functional disability (OR 1.82, 95% CI 1.28-2.60) but was not statistically significant after adjustment (aOR 1.23, 95% CI 0.81-1.86) and was not associated with increased disease activity. Non-white race/ethnicity was associated with higher disease activity (aOR 2.48, 95% CI: 1.41-4.36). Lower self-reported household income was associated with higher disease activity and persistent functional disability. Public insurance (aOR 1.56, 95% CI 1.06-2.29) and low family education (aOR 1.89, 95% CI 1.14-3.12) was associated with persistent functional disability.
Conclusion
High community poverty level was associated with persistent functional disability in unadjusted analysis but not with persistent moderate to high disease activity. Race/ethnicity and other SDH were associated with persistent disease activity and functional disability.
Publisher
Springer Science and Business Media LLC
Subject
Immunology and Allergy,Rheumatology,Pediatrics, Perinatology and Child Health
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