Author:
Salhab Khaled F,Baram Daniel,Bilfinger Thomas V
Abstract
Abstract
Background
Pulmonary histoplasmosis is a mycotic infection that often resembles pulmonary malignancy and continues to complicate the evaluation of pulmonary nodules.
Case presentation
We report a case of an immunocompetent patient who, despite adequate treatment for known histoplasmosis lung infection, presented with radiological and F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) findings mimicking primary lung malignancy which eventually required surgical resection.
Conclusion
Histoplasmosis infection may radiologically resemble pulmonary malignancy, often causing a diagnostic dilemma. PET imaging is currently used for and considered accurate in the evaluation of pulmonary nodules. However, overlap in PET standardized uptake value (SUV) between granulomatous and malignant lesions decreases the accuracy of PET as a diagnostic modality. Future advances in PET imaging are needed to improve its accuracy in the evaluation of pulmonary nodules in areas where histoplasmosis is endemic.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,General Medicine,Surgery,Pulmonary and Respiratory Medicine
Reference14 articles.
1. Edwards LD, Acquaviva FA, Livesay VT, Cross FW, Palmer CE: An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States. Am Rev Respir Dis. 1969, 1-132. Suppl
2. Cano MV, Hajjeh RA: The epidemiology of histoplasmosis: a review. Semin Respir Infect. 2001, 16: 109-18.
3. Goodwin RA, Loyd JE, Des Prez RM: Histoplasmosis in normal hosts. Medicine (Baltimore). 1981, 60: 231-66.
4. Emmons CW: Association of bats with histoplasmosis. Public Health Rep. 1958, 73: 590-5.
5. Eissenberg LG, Goldman WE, Schlesinger PH: Histoplasma capsulatum modulates the acidification of phagolysosomes. J Exp Med. 1993, 177: 1605-11. 10.1084/jem.177.6.1605.
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献