Author:
Boulenouar Houssam,Mediene Benchekor Sounnia,Meroufel Djabaria Naïma,Lardjam Hetraf Sarah Aicha,Ouhaibi Djellouli Hadjira,Hermant Xavier,Grenier-Boley Benjamin,Hamani Medjaoui Imane,Saidi Mehtar Nadhira,Amouyel Philippe,Houti Leila,Meirhaeghe Aline,Goumidi Louisa
Abstract
Abstract
Background
The importance of apolipoprotein E (APOE) in lipid and lipoprotein metabolism is well established. However, the impact of APOE polymorphisms has never been investigated in an Algerian population. This study assessed, for the fist time, the relationships between three APOE polymorphisms (epsilon, rs439401, rs4420638) and plasma lipid concentrations in a general population sample from Algeria.
Methods
The association analysis was performed in the ISOR study, a representative sample of the population living in Oran (787 subjects aged between 30 and 64). Polymorphisms were considered both individually and as haplotypes.
Results
In the ISOR sample, APOE ϵ4 allele carriers had higher plasma triglyceride (p=0.0002), total cholesterol (p=0.009) and LDL-cholesterol (p=0.003) levels than ϵ3 allele carriers. No significant associations were detected for the rs4420638 and rs439401 SNPs. Linkage disequilibrium and haplotype analyses confirmed the respectively deleterious and protective impacts of the ϵ4 and ϵ2 alleles on LDL-cholesterol levels and showed that the G allele of the rs4420638 polymorphism may exert a protective effect on LDL-cholesterol levels in subjects bearing the APOE epsilon 4 allele.
Conclusion
Our results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the ϵ4 allele on LDL-cholesterol levels in an Algerian population.
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Endocrinology, Diabetes and Metabolism
Reference52 articles.
1. Davignon J, Gregg RE, Sing CF: Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988, 8: 1-21. 10.1161/01.ATV.8.1.1
2. Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC: Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 2002, 155: 487-495. 10.1093/aje/155.6.487
3. Transition épidémiologique et système de santé. Synthèse de l'enquête morbidité. 2002, Alger: INSP Ed: Projet TAHINA,
4. Mackay JMG: The Atlas of Heart Disease and Stroke. 2004, Geneva: World Health Organization,
5. , : The World Health Report 2008. 2013, Available from: URL: http://www.who.int/whr/2008/whr08_en.pdf,
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献