Surface patches on recombinant erythropoietin predict protein solubility: engineering proteins to minimise aggregation

Author:

Carballo-Amador M. Alejandro,McKenzie Edward A.,Dickson Alan J.,Warwicker Jim

Funder

CONACyT

Biotechnology and Biological Sciences Research Council

Publisher

Springer Science and Business Media LLC

Subject

Biotechnology

Reference66 articles.

1. Sackmann E: Biological membranes architecture and function. In: Handbook of Biological Physics. Edited by Lipowsky R, Sackmann E, vol. Volume 1. Amsterdam: Elsevier; 1995: 1–63.

2. Krantz SB. Erythropoietin. Blood. 1991;77(3):419–34.

3. Walsh G. Biopharmaceutical benchmarks 2018. Nat Biotechnol. 2018;36:1136.

4. Goldsmith D, Dellanna F, Schiestl M, Krendyukov A, Combe C. Epoetin Biosimilars in the treatment of renal Anemia: what have we learned from a decade of European experience? Clinical drug investigation. 2018;38(6):481–90.

5. Lai PH, Everett R, Wang FF, Arakawa T, Goldwasser E. Structural characterization of human erythropoietin. J Biol Chem. 1986;261(7):3116–21.

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