Author:
Liu Long,Zhang Jiacheng,Sun Jie,Xu Kedi
Abstract
Abstract
Background
Motor cortex stimulation applied as a clinical treatment for neuropathic disorders for decades. With stimulation electrodes placed directly on the cortical surface, this neuromodulation method provides higher spatial resolution than other non-invasive therapies. Yet, the therapeutic effects reported were not in conformity with different syndromes. One of the main issues is that the stimulation parameters are always determined by clinical experience. The lack of understanding about how the stimulation current propagates in the cortex and various stimulation parameters and configurations obstruct the development of this method.
Methods
In this study, we investigated the effect of different stimulation configurations on cortical responses to motor cortical stimulations using intrinsic optical imaging.
Results
Our results showed that the cortical activation of electrical stimulation is not only related to the current density but also related to the propagation distance. Besides, stimulation configurations also affect the propagation of the stimulation current.
Conclusions
All these results provide preliminary experimental evidence for parameter and electrode configuration optimizations.
Funder
Key Technologies Research and Development Program
National Natural Science Foundation of China
Zhejiang Province Public Welfare Technology Application Research Project
Zhejiang Lab
Fundamental Research Funds for the Central Universities
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Biomedical Engineering,General Medicine,Biomaterials,Radiological and Ultrasound Technology
Cited by
3 articles.
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