Author:
de la Poza Abad Mariam,Mas Dalmau Gemma,Moreno Bakedano Mikel,González González Ana Isabel,Canellas Criado Yolanda,Hernández Anadón Silvia,Rotaeche del Campo Rafael,Torán Monserrat Pere,Negrete Palma Antonio,Pera Guillem,Borrell Thió Eulàlia,LLor Carl,Little Paul,Alonso Coello Pablo,
Abstract
Abstract
Background
Respiratory tract infections are an important burden in primary care and it’s known that they are usually self-limited and that antibiotics only alter its course slightly. This together with the alarming increase of bacterial resistance due to increased use of antimicrobials calls for a need to consider strategies to reduce their use. One of these strategies is the delayed prescription of antibiotics.
Methods
Multicentric, parallel, randomised controlled trial comparing four antibiotic prescribing strategies in acute non-complicated respiratory tract infections. We will include acute pharyngitis, rhinosinusitis, acute bronchitis and acute exacerbation of chronic bronchitis or chronic obstructive pulmonary disease (mild to moderate). The therapeutic strategies compared are: immediate antibiotic treatment, no antibiotic treatment, and two delayed antibiotic prescribing (DAP) strategies with structured advice to use a course of antibiotics in case of worsening of symptoms or not improving (prescription given to patient or prescription left at the reception of the primary care centre 3 days after the first medical visit).
Discussion
Delayed antibiotic prescription has been widely used in Anglo-Saxon countries, however, in Southern Europe there has been little research about this topic. The DAP trial wil evaluate two different delayed strategies in Spain for the main respiratory infections in primary care.
Trial registration
This trial is registered with ClinicalTrials.gov, number http://NCT01363531.
Publisher
Springer Science and Business Media LLC
Reference27 articles.
1. Picazo JJ, Pérez-Cecilia E, Herreras A, Grupo DIRA en Atención Primaria: Estudio de las infecciones respiratorias extrahospitalarias. Estudio DIRA. Enferm Infecc Microbiol Clin. 2003, 21: 410-416.
2. Arroll B: Antibiotics for upper respiratory tract infections: an overview of Cochrane reviews. Respir Med. 2005, 99: 255-261. 10.1016/j.rmed.2004.11.004.
3. Arroll B, Kenealy T: Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2005, 3: CD000247
4. Del Mar C, Glasziou P, Spinks AB: Antibiotics for sore throat. Cochrane Database Syst Rev. 2006, 4: CD000023
5. Glasziou P, Del Mar C, Sanders S, Hayem M: Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2004, 1: CD000219
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献