Author:
Aklillu Eleni,Odenthal-Hesse Linda,Bowdrey Jennifer,Habtewold Abiy,Ngaimisi Eliford,Yimer Getnet,Amogne Wondwossen,Mugusi Sabina,Minzi Omary,Makonnen Eyasu,Janabi Mohammed,Mugusi Ferdinand,Aderaye Getachew,Hardwick Robert,Fu Beiyuan,Viskaduraki Maria,Yang Fengtang,Hollox Edward J
Abstract
Abstract
Background
The role of copy number variation of the CCL3L1 gene, encoding MIP1α, in contributing to the host variation in susceptibility and response to HIV infection is controversial. Here we analyse a sub-Saharan African cohort from Tanzania and Ethiopia, two countries with a high prevalence of HIV-1 and a high co-morbidity of HIV with tuberculosis.
Methods
We use a form of quantitative PCR called the paralogue ratio test to determine CCL3L1 gene copy number in 1134 individuals and validate our copy number typing using array comparative genomic hybridisation and fiber-FISH.
Results
We find no significant association of CCL3L1 gene copy number with HIV load in antiretroviral-naïve patients prior to initiation of combination highly active anti-retroviral therapy. However, we find a significant association of low CCL3L1 gene copy number with improved immune reconstitution following initiation of highly active anti-retroviral therapy (p = 0.012), replicating a previous study.
Conclusions
Our work supports a role for CCL3L1 copy number in immune reconstitution following antiretroviral therapy in HIV, and suggests that the MIP1α -CCR5 axis might be targeted to aid immune reconstitution.
Publisher
Springer Science and Business Media LLC
Cited by
19 articles.
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