Author:
Zhong Yan-Wei,Li Jin,Song Hong-Bin,Duan Zhong-Ping,Dong Yi,Xing Xiao-Yan,Li Xiao-Dong,Gu Mei-Lei,Han Yu-Kun,Zhu Shi-Shu,Zhang Hong-Fei
Abstract
Abstract
Background
The association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown.
Methods
Four hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. The stage of fibrosis and degree of inflammatory activity were evaluated by the Metavir score system.
Results
Among 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent (73.7% and 21.1%). Comparing with HBV/B2 infected patients, no significant difference was observed in the incidence rate and mutant patterns of lamivudine- or adefovir-resistant mutations in HBV/C2 infected patients (P > 0.05). Importantly, we found that the degree of hepatic inflammation degree, fibrosis stage and ALT level were significantly higher in HBV/C2-infected HBeAg positive patients than it was in HBV/B2-infected ones.
Conclusions
The pediatric patients with HBV/C2 infection might be more susceptible to develop severe liver pathogenesis.
Publisher
Springer Science and Business Media LLC
Cited by
16 articles.
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