Abstract
Abstract
Background
The success rate of rescue is extremely low in acute paraquat poisoning. This study aimed to assess whether strengthened hemoperfusion (SHP) combined with continuous venovenous hemofiltration (CVVH) improves prognosis in patients with acute paraquat poisoning.
Methods
Patients from January 2005 to December 2018 were enrolled retrospectively. All selected patients were administered conventional therapy. They were divided according to the received treatments in the conventional therapy, hemoperfusion (HP), CVVH, SHP and SHP + CVVH groups. Follow-up was implemented until the 90th day after poisoning. Other outcomes included all-cause mortality on the 15th day after poisoning, and the percentages of respiratory failure and mechanical ventilation use.
Results
The study included 487 patients,and 211 died in all. Mortality rate in the SHP + CVVH group on the 90th day after poisoning was significantly decreased compared with those of other groups (p<0.001). Survival curves of all groups showed significant differences (p<0.001). SHP combined with CVVH was an independent factor reducing mortality risk (p<0.001). Mortality rate in the SHP + CVVH group on the 15th day after poisoning was also significantly decreased (p < 0.05). The proportions of patients in the SHP + CVVH group with acute respiratory failure and mechanical ventilation were significantly lower than those of other groups (p < 0.05).
Conclusions
SHP with CVVH may decrease the mortality rate of patients with acute paraquat poisoning on the 90th day after poisoning and improve the prognosis.
Funder
the AppliedBasic Research Foundation of Yunnan province
the Talent Development Program of The Second Affliated Hospital of Kunming Medical University
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology
Reference23 articles.
1. Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011;72:745–57.
2. Sun L, Yan PB, Zhang Y, Wei LQ, Li GQ. Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning. Exp Ther Med. 2018;15:2688–92.
3. Li A, Li W, Hao F, Wang H. Early stage blood purification for Paraquat poisoning: a multicenter retrospective study. Blood Purif. 2016;42:93–9.
4. Li C, Hu D, Xue W, Li X, Wang Z, Ai Z, et al. Treatment outcome of combined continuous Venovenous hemofiltration and Hemoperfusion in acute Paraquat poisoning: a prospective controlled trial. Crit Care Med. 2018;46:100–7.
5. Zhao X, Xiao Y, Zhu J, Xu Z, Liu L, Zhang J. Prognostic comparison of goal-oriented hemoperfusion and routine hemoperfusion combined with continuous venovenous hemofiltration for paraquat poisoning. J Int Med Res. 2018;46:1091–102.
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