Abstract
Abstract
Background
A novel RNA coronavirus was identified in January 2020 as the cause of a pneumonia epidemic affecting the city of Wuhan; it rapidly spread across China.
Aim of the review
The aim is to discuss the potential efficacy of some pharmacologically known pharmacological antidotes (N-acetylcysteine; hyperbaric oxygen; deferoxamine; low-dose naloxone) for the management of COVID-19-associated symptoms and complications.
Method
An extensive search was accomplished in Medline, Embase, Scopus, Web of Science, and Central databases until the end of April, 2021. Four independent researchers completed the screening, and finally, the associated studies were involved.
Conclusion
The current proof hinders the experts for suggesting the proper pharmacological lines of treatment of COVID-19. Organizations, for example, WHO, should pursue more practical actions and design well-planned clinical trials so that their results may be used in the treatment of future outbreaks.
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science,General Medicine
Reference120 articles.
1. Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H et al (2020) First case of 2019 novel coronavirus in the United States. N Engl J Med 382:929–936
2. Remuzzi A, Remuzzi G (2020) COVID-19 and Italy: what next? Lancet 395:1225–1228
3. Stoecklin SB, Rolland P, Silue Y, Mailles A, Campese C, Simondon A et al (2020) First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020. Eurosurveillance 25(6):2000094
4. Cheng MP, Papenburg J, Desjardins M, Kanjilal S, Quach C, Libman M et al (2020) Diagnostic testing for severe acute respiratory syndrome–related coronavirus-2: a narrative review. Ann Intern Med 172(11):726-34
5. Liu J, Liao X, Qian S, Yuan J, Wang F, Liu Y et al (2020a) Community transmission of severe acute respiratory syndrome coronavirus 2, Shenzhen, China, 2020. Emerg Infect Dis 26(6):1320.