Author:
Gerveieeha Zohre,Siassi Fereydoun,Qorbani Mostafa,Menbar Rezgar Shahi,Ahmadi Mohammad Hossein,Sotoudeh Gity
Abstract
Abstract
Background
This study aimed to evaluate the effect of vitamin D3 supplementation on body composition and anthropometric measures of nursing mothers.
Methods
In a double-blind, randomized clinical trial, 90 nursing mothers with overweight or obesity were randomized into three groups for 12 weeks: two groups of vitamin D3 supplementation (2000 IU/d (VD1), n = 32 and 4000 IU/d (VD2), n = 29) and placebo (PL) group (n = 29). The information on body composition was obtained using the body impedance analysis (BIA) method. Serum 25-Hydroxy vitamin D (25(OH) D), Intact Parathyroid Hormone (iPTH), calcium, and phosphorus were measured before and after the intervention. Data were analyzed based on the intention-to-treat (ITT) method. Two-way repeated measure ANOVA (mixed ANOVA) was applied to assess whether the mean changes in the results from baseline to 12 weeks differ in the three groups.
Results
There was a significant increase in the serum 25(OH) D concentration in the VD2 group compared to VD1 and PL groups (mean change (MC), 12.3 ng/ml; 95% CI, 9.4/15.0, p-value < 0.001). In addition, fat mass (MC, − 4.3 kg; 95% CI, − 7.0/− 1.1, p-value < 0.007), fat mass index (MC, − 1.6; 95% CI, − 2.6/− 0.5, p-value < 0.006) and body fat percentage (MC, − 8.1; 95% CI, − 12.0/− 4.2, p-value < 0.007) reduced in VD2 group as compared with VD1 and PL groups.
Conclusion
The intake of 4000 IU/d vitamins D3 supplementation would elevate circulating 25(OH) D concentrations in nursing mothers with overweight or obesity and improve some indices of body composition.
Trial registration
Iranian Registry of Clinical Trials (http://www.irct.ir: IRCT20140413017254N6) registered on 11-04-2018.
Graphical Abstract
The graphical abstract of this clinical trial, is a figure that explains the final results of the manuscript in a clear and attractive way
Funder
Tehran University of Medical Sciences and Health Services
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
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