Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (AT2R) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies-Reference-Cited by-同舟云学术

Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (AT2R) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies

Published:2015-06-26 Issue: Volume:11 Page:s12990-015-0038
ISSN:1744-8069
Container-title:Molecular Pain
language:en
Short-container-title:Mol Pain

Author:

Anand Uma¹²,Yiangou Yiangos¹,Sinisi Marco¹³,Fox Michael¹³,MacQuillan Anthony¹³,Quick Tom¹³,Korchev Yuri E²,Bountra Chas⁴,McCarthy Tom⁵,Anand Praveen¹

Affiliation:

1. Peripheral Neuropathy Unit, Centre for Clinical Translation, Hammersmith Hospital, Imperial College London, Area A, Ground Floor, Du Cane Rd, London W12 ONN, UK

2. Nanomedicine Research Laboratory, Division of Medicine, Hammersmith Hospital, Imperial College London, BN5 Commonwealth Building, London W12 0NN, UK

3. Peripheral Nerve Injury Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP, UK

4. University of Oxford Structural Genomics Consortium, Old Road, Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK

5. Spinifex Pharmaceuticals Pty Ltd, Corporate One, Suite G5, 84 Hotham St, Preston, VIC 3072, Australia

Publisher

SAGE Publications

Subject

Anesthesiology and Pain Medicine,Cellular and Molecular Neuroscience,Molecular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1186/s12990-015-0038-x

Reference38 articles.

1. A Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonist Produces Analgesia in a Rat Model of Neuropathic Pain by Inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK Activation in the Dorsal Root Ganglia

2. Angiotensin II type 2 receptor ( AT 2 R ) localization and antagonist‐mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons

3. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial

4. cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation

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