Author:
Nakra Tripti,Dadhwal Rohit,Nayyar Rishi,Rastogi Sameer,Kakkar Aanchal,Sharma Mehar Chand,Yadav Rajni
Abstract
Abstract
Background
Primary malignant melanoma of the female urethra is an exceedingly rare tumor. It represents 0.2% of all malignant melanomas. Divergent differentiation towards non-melanocytic lineages has not been reported in urethral melanoma.
Case presentation
We report a rare case of neuroendocrine differentiation in a large primary small cell malignant melanoma involving the urethra, in a 62-year-old lady, who presented with obstructive urinary symptoms. Clinical and radiological workup revealed a large urethral mass with liver and lymph nodal metastases. A biopsy was performed from the urethral and liver lesions which showed poorly differentiated tumor cells with small cell morphology and presence of melanin pigment. These cells were immunopositive for melanocytic and neuroendocrine markers. Ultrastructural examination showed presence of melanosomes and neurosecretory granules in the tumor cells.
Conclusions
Although malignant melanoma with neuroendocrine differentiation is exceptionally rare, it needs to be recognized among the other well-known variants of malignant melanoma.
Publisher
Springer Science and Business Media LLC
Reference12 articles.
1. Oliva E, Quinn TR, Amin MB, et al. Primary malignant melanoma of the urethra: a clinicopathologic analysis of 15 cases. Am J Surg Pathol. 2000;24:785–96.
2. Cho ST, Song HC, Cho B, et al. Primary malignant melanoma of the female urethra. Korean J Urol. 2012;53:206–8.
3. Pandey PK, Vijay MK, Goel H, Shukla S. Primary malignant melanoma of female urethra: a rare neoplasm. J Cancer Res Ther. 2014;10:758–60.
4. Banerjee SS, Eyden B. Divergent differentiation in malignant melanomas: a review. Histopathology. 2008;52:119–29.
5. Kim CJ, Pak K, Hamaguchi A, et al. Primary malignant melanoma of the female urethra. Cancer. 1993;71:448–51.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献