Author:
Kantar Ahmad,Mazza Angelo,Bonanomi Ezio,Odoni Marta,Seminara Manuela,Verde Ilaria Dalla,Lovati Camillo,Bolognini Stefania,D’Antiga Lorenzo
Abstract
Abstract
Background
Down syndrome (DS) is characterized by a series of immune dysregulations, of which interferon hyperreactivity is important, as it is responsible for surging antiviral responses and the possible initiation of an amplified cytokine storm. This biological condition is attributed to immune regulators encoded in chromosome 21. Moreover, DS is also characterized by the coexistence of obesity and cardiovascular and respiratory anomalies, which are risk factors for coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Case presentation
A total of 55 children were admitted to the pediatric ward in Bergamo, between February and May 2020 for COVID-19. Here, we describe the cases of two children with DS and a confirmed COVID-19 diagnosis who had a severe course. In addition, both cases involved one or more comorbidities, including cardiovascular anomalies, obesity, and/or obstructive sleep apnea.
Conclusions
Our observations indicate that children with DS are at risk for severe COVID-19 disease course.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology, and Child Health
Cited by
23 articles.
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