Author:
Yang Si-Si,Huang Wen-Chang,Wang Peng,Gong Fang-Qi,Liu Tai-Xiang,Tou Jin-Fa,Lai Deng-Ming
Abstract
Abstract
Purpose
The purpose of this study was to explore echocardiographic parameters of the left ventricle (LV) in relation to the outcomes of omphalocele neonates with pulmonary hypertension (PH).
Methods
This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have additional severe malformations or chromosomal aberrations. Patients who died under palliative care were excluded. The echocardiographic parameters of LV were obtained within 24 h after birth. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal dimension in end-diastole (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others.
Results
There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Both groups were comparable in the baseline characteristics. Non-survival was associated with a smaller LV [LVIDd (12.2 mm versus15.7 mm, p < 0.05), EDV (3.5 ml versus 6.8 ml, p < 0.05)] and with worse systolic function [SV (2.3 ml versus 4.2 ml, p < 0.05), and CI (1.7 L/min/m2 versus 2.9 L/min/m2, p < 0.01)].
Conclusion
In the cohort of omphalocele patients with PH, lower LVIDd, EDV, SV and CI were associated with mortality.
Level of evidence
Level III.
Funder
Scientific Research Fund of Zhejiang University
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Foundation for The Top-Notch Youth Talent Cultivation Project of Independent Design Project of National Clinical Research Center for Child Health
Special Fund for the Incubation of Young Clinical Scientist, Children’s Hospital, Zhejiang University School of Medicine
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health