Author:
Farnaghi Fariba,Rahmani Razieh,Hassanian-Moghaddam Hossein,Zamani Nasim,McDonald Rebecca,Gholami Narges,Gachkar Latif
Abstract
Abstract
Objectives
To evaluate the efficacy of oral clonazepam versus oral lorazepam following initial parenteral benzodiazepine administration to control methamphetamine-induced agitation in children.
Methods
In a single-center clinical trial, intravenous diazepam (0.2 mg/Kg) was initially administered to all methamphetamine-poisoned pediatric patients to control their agitation, followed by a single dose of oral clonazepam (0.05 mg/Kg; n = 15) or oral lorazepam (0.05 mg/Kg; n = 15) to prevent relapse of toxicity.
Results
The median age [IQR] (range) was 15 [10, 36] (6-144) months. The source of poisoning was methamphetamine exposure from oral ingestion in 23 (76.7%) and passive inhalation in 7 (23.3%) patients. The most common symptoms/signs were agitation (29; 96.7%), mydriatic pupils (26; 86.7%), and tachycardia (20; 66.6%). Two in each group (13.3%) needed re-administration of intravenous diazepam due to persistent agitation. There was no report of benzodiazepine complications in either group.
Conclusions
Clonazepam and lorazepam treatment was equally effective at similar doses. However, considering the higher potency of clonazepam, it seems that lorazepam is the safer benzodiazepine for oral maintenance treatment of methamphetamine-induced agitation in children and can be used with minimal complications.
Trial registration
IRCT20180610040036N2, April 18th, 2020. Retrospectively registered.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Reference23 articles.
1. Hassanian-Moghaddam H, Ranjbar M, Farnaghi F, Zamani N, Alizadeh AM, Sarjami S. Stimulant Toxicity in Children: A Retrospective Study on 147 Patients. Pediatr Crit Care Med. 2015;16:e290-6.
2. Hassanian-Moghaddam H, Zamani N, Rahimi M, Shadnia S, Pajoumand A, Sarjami S. Acute adult and adolescent poisoning in Tehran, Iran; the epidemiologic trend between 2006 and 2011. Arch Iran Med. 2014;17:534–8.
3. Bahrami-Motlagh H, Hassanian-Moghaddam H, Zamini H, Zamani N, Gachkar L. Correlation of abdominopelvic computed tomography with clinical manifestations in methamphetamine body stuffers. Radiol Med. 2018;123:98–104.
4. Abbasi A, Taziki S, Moradi A. The prototype of drug disabused of opioids in the self-introduced addicts in Gorgan (North-East of Iran). Journal of Gorgan University of Medical Sciences. 2006;1:22–7. (Persian).
5. Bernstein D, Shelov SP. Pediatrics for Medical Students. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2011.
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