Successful treatment of Henoch-Schönlein purpura-associated hematochezia in a child with hemophilia A: a case report

Author:

Feng KaiORCID,Liu Chang,Zhang Keqing,Hao Jing

Abstract

Abstract Background Henoch-Schönlein purpura (HSP) is a common form of immunological vasculitis in children. Hemophilia A is a genetic disorder and characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII deficiency. Both diseases increase the risk of bleeding, but they have different mechanisms. How should we treat patients with both diseases? Case presentation An 8-year-old male with hemophilia A was diagnosed with HSP while receiving coagulation factor VIII replacement therapy in our hospital. Hematochezia occurred 6 days after the diagnosis of HSP. And he treated with coagulation FVIII, methylprednisolone and hemostatic drugs. Conclusions There is no causal relationship between hemophilia A and HSP, but both diseases can cause bleeding. This child's hematochezia was caused by HSP, but hemophilia could not be ignored during the treatment. Our case report adds to the present body of knowledge about the treatment of HSP associated hematochezia in a child with hemophilia A.

Publisher

Springer Science and Business Media LLC

Subject

Pediatrics, Perinatology and Child Health

Reference24 articles.

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3. Jia DC, Liu BN, Luo JH. Research progress in recombinant coagulation factor VIII products and their pharmaceutical assessment. Chin J New Drugs. 2019;28(14):1681–7.

4. Stacy PAEF. Henoch- Schönlein purpura. In: Kliegman RM, editor. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: Elsevier Saunders; 2016. p. 1216–8.

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