Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study

Author:

Muniz Alessandra Karla Oliveira AmorimORCID,Ribeiro Cecilia Claudia CostaORCID,Vianna Elcio OliveiraORCID,Serra Hellen Cristina Oliveira AmorimORCID,Nascimento Joelma Ximenes Prado TeixeiraORCID,Cardoso Viviane CunhaORCID,Barbieri Marco AntonioORCID,da Silva Antonio Augusto MouraORCID,Bettiol HeloisaORCID

Abstract

Abstract Background Allergic status has been strongly influenced by early exposures; however, allergic diseases are hard to measure in early life. Thus, this study proposed a latent variable allergy traits around the second year of life and analyzed pre- and perinatal factors associated with this phenomenon. Methods The study used data from the BRISA birth cohort, Ribeirão Preto, Brazil (n = 3644). The theoretical model included: family allergy (history of allergic rhinitis, atopic dermatitis, and asthma); gestational period variables (socioeconomic status, mother’s skin color, pregestational body mass index – BMI, smoking, gestational diabetes, and hypertension); birth variables (gestational age, 5-minute Apgar score, birth weight, type of delivery), and early life factor (exclusive breast feeding). The outcome was allergy traits around the 2nd year of life, a latent variable deduced from the shared variance among medical diagnosis of allergic rhinitis, atopic dermatitis, and food allergy. The model was analyzed by structural equation modeling. Results Higher socioeconomic status (SC = 0.256; p < 0.001) and higher family allergy values (SC = 1.224; p < 0.001) were associated with higher allergy trait values. Hypertension during pregnancy was associated with higher values (SC = 0.170; p = 0.022) and exclusive breast feeding (SC = -0.192; p < 0.001) with low allergy trait values. Conclusion Although socioeconomic and environmental factors were associated with allergy traits around the 2nd year of life, the family component of allergy was the exposure that best explained this outcome.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Research Support Foundation of the State of São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Springer Science and Business Media LLC

Subject

Pediatrics, Perinatology and Child Health

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