Author:
Liu Yue,Du Xiaofan,Zhai Shujie,Tang Xiaodong,Liu Cuiling,Li Weihong
Abstract
Abstract
Background
Gut microbiota plays an important role in the development of atopic dermatitis (AD). We aimed to elucidate research trends in gut microbiota and AD in children, to provide evidence and insights to the clinical prevention and treatment of AD in children.
Methods
A scoping literature review on the studies of gut microbiota and AD were conducted. Two authors independently searched Pubmed et al. databases for studies focused on gut microbiota and AD in children up to January 15, 2022. The literatures were screened and analyzed by two reviewers.
Results
A total of 44 reports were finally included and analyzed. Current researches have indicated that abnormal human microecology is closely associated with AD, and the disturbance of intestinal microbiota plays an important role in the occurrence and development of AD. Probiotics can correct the microbiota disorder, have the functions of regulating immunity, antioxidant, and help to restore the microecological homeostasis. However, there is still a lack of high-quality research reports on the efficacy and safety of probiotics in the prevention and treatment of AD in children.
Conclusions
The changes of gut microbiota are essential to the development of AD in children, which may be an effective target for the prevention and treatment of AD. Future studies with larger sample size and rigorous design are needed to elucidate the effects and safety of probiotics in AD.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Reference69 articles.
1. Bieber T. Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat Rev Drug Discov. 2022;21(1):21–40.
2. Kiiski V, Salava A, Susitaival P, Barnhill S, Remitz A, Heliovaara M. Atopic dermatitis in adults: a population-based study in Finland. Int J Dermatol. 2022;61(3):324–30.
3. Xiaoyan L, Quan G, Caibin G. The correlation between the severity of atopic dermatitis in children and NLR. Modern Med Health. 2021;37(7):3–6.
4. Sulian Y, Yang X, Guoxing Z. Clinical analysis of serum specific IgE and patch test results in children with atopic dermatitis. Chinese J Immunol. 2021;37(1):5–7.
5. Yanlin Z, Jianbo W. Expression of serum 25-hydroxyvitamin D in children with atopic dermatitis and its clinical significance. Jilin Medicine. 2020;41(10):3–4.
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献