Author:
Han Phuu P,Nagatsuka Hitoshi,Siar Chong H,Tsujigiwa Hidetsugu,Gunduz Mehmet,Tamamura Ryo,Borkosky Silvia S,Katase Naoki,Nagai Noriyuki
Abstract
Abstract
Background
Pigmented intraosseous odontogenic lesions are rare with only 47 reported cases in the English literature. Among them, pigmented calcifying cystic odontogenic tumor, formerly known as calcifying odontogenic cyst, is the most common lesion with 20 reported cases.
Methods
A case of pigmented calcifying cystic odontogenic tumor associated with odontoma occurring at the mandibular canine-premolar region of a young Japanese boy is presented with radiographic, and histological findings. Special staining, electron microscopic study and immunohistochemical staining were also done to characterize the pigmentation.
Results
The pigments in the lesion were confirmed to be melanin by Masson-Fontana staining and by transmission electron microscopy. The presence of dendritic melanocytes within the lesion was also demonstrated by S-100 immunostaining.
Conclusion
The present case report of pigmented calcifying cystic odontogenic tumor associated with odontoma features a comprehensive study on melanin and melanocytes, including histochemical, immunohistochemical and transmission electron microscopic findings.
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Dentistry,Otorhinolaryngology
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