Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
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Published:2019-02-11
Issue:1
Volume:7
Page:
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ISSN:2051-1426
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Container-title:Journal for ImmunoTherapy of Cancer
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language:en
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Short-container-title:j. immunotherapy cancer
Author:
Smith Kellie N., Llosa Nicolas J., Cottrell Tricia R., Siegel Nicholas, Fan Hongni, Suri Prerna, Chan Hok Yee, Guo Haidan, Oke Teniola, Awan Anas H., Verde Franco, Danilova Ludmila, Anagnostou Valsamo, Tam Ada J., Luber Brandon S., Bartlett Bjarne R., Aulakh Laveet K., Sidhom John-William, Zhu Qingfeng, Sears Cynthia L., Cope Leslie, Sharfman William H., Thompson Elizabeth D., Riemer Joanne, Marrone Kristen A., Naidoo Jarushka, Velculescu Victor E., Forde Patrick M., Vogelstein Bert, Kinzler Kenneth W., Papadopoulos Nickolas, Durham Jennifer N., Wang Hao, Le Dung T., Justesen Sune, Taube Janis M., Diaz Luis A., Brahmer Julie R., Pardoll Drew M., Anders Robert A., Housseau FranckORCID
Funder
National Cancer Institute Cancer Research Institute Stand Up To Cancer Commonwealth Foundation
Subject
Cancer Research,Pharmacology,Oncology,Molecular Medicine,Immunology,Immunology and Allergy
Reference25 articles.
1. Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med. 2015;372:2509–20. 2. Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124–8. 3. Hellmann MD, Ciuleanu TE, Pluzanski A, Lee JS, Otterson GA, Audigier-Valette C, et al. Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. N Engl J Med. 2018;378:2093–104. 4. Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov. 2015;5:43–51. 5. Wong CW, Fan YS, Chan TL, Chan AS, Ho LC, Ma TK, et al. BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs. J Clin Pathol. 2005;58:640–4.
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