Author:
Mao Misha,Cheng Yifan,Yang Jingjing,Chen Yongxia,Xu Ling,Zhang Xun,Li Zhaoqing,Chen Cong,Ju Siwei,Zhou Jichun,Wang Linbo
Abstract
AbstractThe role of PLAC8 in tumorigenesis has been gradually elucidated with the development of research. Although there are common molecular mechanisms that enforce cell growth, the impact of PLAC8 is varied and can, in some instances, have opposite effects on tumorigenesis. To systematically understand the role of PLAC8 in tumors, the molecular functions of PLAC8 in cancer will be discussed by focusing on how PLAC8 impacts tumorigenesis when it arises within tumor cells and how these roles can change in different stages of cancer progression with the ultimate goal of suppressing PLAC8-relevant cancer behavior and related pathologies. In addition, we highlight the diversity of PLAC8 in different tumors and its functional output beyond cancer cell growth. The comprehension of PLAC8’s molecular function might provide new target and lead to the development of novel anticancer therapies.
Funder
national natural science foundation of china
natural science foundation of zhejiang province
zhejiang provincial key laboratory of wood science and technology
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry (medical),Clinical Biochemistry,Molecular Medicine
Cited by
20 articles.
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