Targeting ferroptosis in breast cancer

Author:

Li Zhaoqing,Chen Lini,Chen Cong,Zhou Yulu,Hu Dengdi,Yang Jingjing,Chen Yongxia,Zhuo Wenying,Mao Misha,Zhang Xun,Xu Ling,Wang Linbo,Zhou JichunORCID

Abstract

Abstract Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Zheng Shu Medical Elite Scholarship Fund

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Medicine

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