Author:
Ma Jie,Zhou Miao,Song Zehe,Deng Yuankun,Xia Siting,Li Yunxia,Huang Xingguo,Xiao Dingfu,Yin Yulong,Yin Jie
Abstract
Abstract
Background
Compared to that of bacteria, the role of gut fungi in obesity development remains unknown.
Results
Here, alterations in gut fungal biodiversity and composition were confirmed in obese pig models and high-fat diet (HFD)-fed mice. Antifungal drugs improved diet-induced obesity, while fungal reconstruction by cohousing or fecal microbiota transplantation maintained the obese phenotype in HFD-fed mice. Fungal profiling identified 5 fungal species associated with obesity. Specifically, Ascomycota_sp. and Microascaceae_sp. were reduced in obese mice and negatively correlated with fat content. Oral supplementation with fungi was sufficient to prevent and treat diet-induced obesity. Clec7a, which is involved in fungal recognition, was highly expressed in HFD-fed mice. The Clec7a agonist accelerated diet-induced obesity, while Clec7a deficieny in mice resulted in resistance to diet-induced obesity and blocked the anti-obese effect of antifungal drugs and fungi.
Conclusions
Taken together, these results indicate that gut fungi/Clec7a signaling is involved in diet-induced obesity and may have therapeutic implications as a biomarker for metabolic dysregulation in humans.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Earmarked Fund for China Agriculture Research System
Publisher
Springer Science and Business Media LLC
Subject
Microbiology (medical),Microbiology
Cited by
4 articles.
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