Combination therapy for melanoma with BRAF/MEK inhibitor and immune checkpoint inhibitor: a mathematical model

Author:

Lai Xiulan,Friedman Avner

Funder

National Science Foundation

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Applied Mathematics,Computer Science Applications,Molecular Biology,Modeling and Simulation,Structural Biology

Reference91 articles.

1. Cheng X, Veverka V, Radhakrishnan A, Waters LC, Muskett FW, Morgan SH, et al. Human pd-l1/b7-h1/cd274 protein. Sino Biological Inc. http://www.sinobiological.com/PD-L1-B7-H1-CD274-Protein-g-533.html . Accessed 2002.

2. Shi L, Chen S, Yang L, Li Y. The role of pd-1 and pd-l1 in t-cell immune suppression in patients with hematological malignancies. J Hematol Oncol. 2013; 6(74):10–118617568722674.

3. Muppidi MR, George S. Immune checkpoint inhibitors in renal cell carcinoma. J Targeted Ther Cancer. 2015; 4:47–52.

4. Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, et al. Response to braf inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014; 2(7):643–54.

5. Wilmott JS, Long GV, Howle JR, Haydu LE, Sharma RN, Thompson JF, et al. Selective braf inhibitors induce marked t-cell infiltration into human metastatic melanoma. Clin Cancer Res. 2012; 18(5):1386–94.

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