Author:
Brown Robin,Donnelly Deirdre E,Allen Derek,Loughrey Maurice B,Morrison Patrick J
Abstract
Abstract
Objective
Familial Urothelial cell bladder cancer is rare. We report two families with urothelial cell carcinoma (UCC) of bladder with family history in other relatives, displaying probable autosomal dominant inheritance and a late onset pure UCC phenotype, and document the phenotype in each family.
Methods
Descriptive familial study on two pedigrees over three generations.
Results
Two families with UCC bladder were identified, and the phenotype documented, each family having three cases of late onset UCC.
Conclusion
Some cases of UCC are hereditary and may display autosomal dominant inheritance with late onset of the cancer. Clinicians should be aware of the existence of a familial late onset UCC phenotype when managing cases of UCC.
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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